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Professor, Alpert Medical School at Brown University

This muscle divides the neck into anterior and posterior triangles when viewed from the side (Figure 11 prehypertension causes cheap inderal generic. Muscles That Move the Head Target motion Movement Target Prime mover Origin Insertion direction Temporal Rotates and Individually: rotates bone tilts head to the Skull; head to opposite side; Sternocleidomastoid Sternum; clavicle (mastoid side; tilts head vertebrae bilaterally: flexion process); forward occipital bone Individually: laterally Transverse and Rotates and Skull; flexes and rotates articular processes Occipital tilts head Semispinalis capitis vertebrae head to same side; of cervical and bone backward bilaterally: extension thoracic vertebra Temporal Rotates and Individually: laterally Spinous processes bone tilts head to the Skull; flexes and rotates Splenius capitis of cervical and (mastoid side; tilts head vertebrae head to same side; thoracic vertebra process); backward bilaterally: extension occipital bone Rotates and Individually: laterally Transverse and Temporal tilts head to the Skull; flexes and rotates articular processes bone Longissimus capitis side; tilts head vertebrae head to same side; of cervical and (mastoid backward bilaterally: extension thoracic vertebra process) Table 11 heart attack mayo clinic generic inderal 10mg without prescription. The back muscles stabilize and move the vertebral column blood pressure parameters buy generic inderal 40 mg on line, and are grouped according to the lengths and direction of the fascicles. From the sides and the back of the neck, the splenius capitis inserts onto the head region, and the splenius cervicis extends onto the cervical region. The erector spinae group forms the majority of the muscle mass of the back and it is the primary extensor of the vertebral column. It controls flexion, lateral flexion, and rotation of the vertebral column, and maintains the lumbar curve. The erector spinae comprises the iliocostalis (laterally placed) group, the longissimus (intermediately placed) group, and the spinalis (medially placed) group. The iliocostalis group includes the iliocostalis cervicis, associated with the cervical region; the iliocostalis thoracis, associated with the thoracic region; and the iliocostalis lumborum, associated with the lumbar region. The three muscles of the longissimus group are the longissimus capitis, associated with the head region; the longissimus cervicis, associated with the cervical region; and the longissimus thoracis, associated with the thoracic region. The third group, the spinalis group, comprises the spinalis capitis (head region), the spinalis cervicis (cervical region), and the spinalis thoracis (thoracic region). The transversospinales muscles run from the transverse processes to the spinous processes of the vertebrae. Similar to the erector spinae muscles, the semispinalis muscles in this group are named for the areas of the body with which they are associated. The semispinalis muscles include the semispinalis capitis, the semispinalis cervicis, and the semispinalis thoracis. The multifidus muscle of the lumbar region helps extend and laterally flex the vertebral column. These muscles bring together the spinous and transverse processes of each consecutive vertebra. Finally, the scalene muscles work together to flex, laterally flex, and rotate the head. The scalene muscles include the anterior scalene muscle (anterior to the middle scalene), the middle scalene muscle (the longest, intermediate between the anterior and posterior scalenes), and the posterior scalene muscle (the smallest, posterior to the middle scalene). The muscles of the vertebral column, thorax, and abdominal wall extend, flex, and stabilize different parts of the body’s trunk. The deep muscles of the core of the body help maintain posture as well as carry out other functions. The brain sends out electrical impulses to these various muscle groups to control posture by alternate contraction and relaxation. Muscles of the Abdomen There are four pairs of abdominal muscles that cover the anterior and lateral abdominal region and meet at the anterior midline. These muscles of the anterolateral abdominal wall can be divided into four groups: the external obliques, the internal obliques, the transversus abdominis, and the rectus abdominis (Figure 11. On the flanks of the body, medial to the rectus abdominis, the abdominal wall is composed of three layers. The external oblique muscles form the superficial layer, while the internal oblique muscles form the middle layer, and the transverses abdominus forms the deepest layer. The external oblique, closest to the surface, extend inferiorly and medially, in the direction of sliding one’s four fingers into pants pockets. Perpendicular to it is the intermediate internal oblique, extending superiorly and medially, the direction the thumbs usually go when the other fingers are in the pants pocket. The deep muscle, the transversus abdominis, is arranged transversely around the abdomen, similar to the front of a belt on a pair of pants.

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Its close association with + Na in the extracellular environment makes it the dominant anion of this compartment blood pressure standards buy inderal now, and its regulation closely mirrors + that of Na arrhythmia specialist 80 mg inderal visa. It is rapid but has limited2 capacity in the face of a significant acid challenge lennox pulse pressure test kit buy inderal without a prescription. In the collecting ducts, the apical surfaces of intercalated cells have + proton pumps that actively secrete H into the luminal, forming urine to remove it from the body. Proteins are broken down into amino acids, which in turn are deaminated by having their nitrogen groups removed. Ammonia is extremely toxic, so most of it is very rapidly converted into urea in the liver. Human urinary wastes typically contain primarily urea with small amounts of ammonium and very little uric acid. Drugs that are structurally small can be filtered by the glomerulus with the filtrate. Large drug molecules such as heparin or those that are bound to plasma proteins cannot be filtered and are not readily eliminated. Some drugs can be eliminated by carrier proteins that enable secretion of the drug into the tubule lumen. There are specific carriers that eliminate basic (such as dopamine or histamine) or acidic drugs (such as penicillin or indomethacin). As is the case with other substances, drugs may be both filtered and reabsorbed passively along a concentration gradient. A change in one system may affect all other systems in the body, with mild to devastating effects. A failure of urinary continence can be embarrassing and inconvenient, but is not life threatening. Activated vitamin D is important for absorption of ++ ++ Ca in the digestive tract, its reabsorption in the kidney, and the maintenance of normal serum concentrations of Ca and phosphate. Calcium is vitally important in bone health, muscle contraction, hormone secretion, and neurotransmitter release. Deficits may also result in problems with cell proliferation, neuromuscular function, blood clotting, and the inflammatory response. Recent research has confirmed that vitamin D receptors are present in most, if not all, cells of the body, reflecting the systemic importance of vitamin D. Many scientists have suggested it be referred to as a hormone rather than a vitamin. If you move to a higher altitude, the partial pressure of oxygen is lower, meaning there is less pressure to push oxygen across the alveolar membrane and into the red blood cell. Much of the water the kidneys recover from the forming urine follows the + reabsorption of Na. Normally, all of the glucose is recovered, but loss of glucose control (diabetes mellitus) may result in an osmotic dieresis severe enough to produce severe dehydration and death. A loss of renal function means a loss of effective vascular volume control, leading to hypotension (low blood pressure) or hypertension (high blood pressure), which can lead to stroke, heart attack, and aneurysm formation. The kidneys cooperate with the lungs, liver, and adrenal cortex through the renin–angiotensin–aldosterone system (see Figure 25. The reabsorption of Na helps to raise and maintain blood pressure over a longer term.

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Moreover demi lovato heart attack mp3 buy cheap inderal 10mg on line, circulating triglycerides and cholesterol can seep between the damaged lining cells and become trapped within the artery wall blood pressure 7860 order inderal no prescription, where they are frequently joined by leukocytes arteria peronea buy inderal 80 mg without prescription, calcium, and cellular debris. Eventually, this buildup, called plaque, can narrow arteries enough to impair blood flow. The term for this condition, atherosclerosis (athero= “porridge”) describes the mealy deposits (Figure 20. This clot can further obstruct the artery and—if it occurs in a coronary or cerebral artery—cause a sudden heart attack or stroke. Alternatively, plaque can break off and travel through the bloodstream as an embolus until it blocks a more distant, smaller artery. Even without total blockage, vessel narrowing leads to ischemia—reduced blood flow—to the tissue region “downstream” of the narrowed vessel. Hypoxia involving cardiac muscle or brain tissue can lead to cell death and severe impairment of brain or heart function. A major risk factor for both arteriosclerosis and atherosclerosis is advanced age, as the conditions tend to progress over time. Arteriosclerosis is normally defined as the more generalized loss of compliance, “hardening of the arteries,” whereas atherosclerosis is a more specific term for the build-up of plaque in the walls of the vessel and is a specific type of arteriosclerosis. There is also a distinct genetic component, and pre-existing hypertension and/or diabetes also greatly increase the risk. However, obesity, poor nutrition, lack of physical activity, and tobacco use all are major risk factors. Treatment includes lifestyle changes, such as weight loss, smoking cessation, regular exercise, and adoption of a diet low in sodium and saturated fats. To prevent subsequent collapse of the vessel, a small mesh tube called a stent is often inserted. This operation is typically performed on the carotid arteries of the neck, which are a prime source of oxygenated blood for the brain. In a coronary bypass procedure, a non-vital superficial vessel from another part of the body (often the great saphenous vein) or a synthetic vessel is inserted to create a path around the blocked area of a coronary artery. Venous System the pumping action of the heart propels the blood into the arteries, from an area of higher pressure toward an area of lower pressure. If blood is to flow from the veins back into the heart, the pressure in the veins must be greater than the pressure in the atria of the heart. First, the pressure in the atria during diastole is very low, often approaching zero when the atria are relaxed (atrial diastole). Skeletal Muscle Pump In many body regions, the pressure within the veins can be increased by the contraction of the surrounding skeletal muscle. As leg muscles contract, for example during walking or running, they exert pressure on nearby veins with their numerous one-way valves. This increased pressure causes blood to flow upward, opening valves superior to the contracting muscles so blood flows through. Simultaneously, valves inferior to the contracting muscles close; thus, blood should not seep back downward toward the feet. Military recruits are trained to flex their legs slightly while standing at attention for prolonged periods.

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Sodium ions that enter the cell at the initial segment start to spread along + the length of the axon segment hypertension 160100 purchase line inderal, but there are no voltage-gated Na channels until the frst node of Ranvier heart attack ekg buy inderal 80mg otc. Because there is not constant opening of these channels along the axon segment blood pressure medication spironolactone side effects generic 40mg inderal otc, the depolarization spreads at an optimal speed. The distance between nodes is the optimal distance to keep the membrane still depolar+ ized above threshold at the next node. As Na spreads along the inside of the membrane of the axon segment, the charge starts to dissipate. If the node were any farther down the axon, that depolarization would have + fallen of too much for voltage-gated Na channels to be activated at the next node of Ranvier. Propagation along an unmyelinated axon is referred to as continuous conduction; along the length of a myelinated axon, it is saltatory conduction. Continuous conduction is slow because there are always volt+ + age-gated Na channels opening, and more and more Na is rushing into the cell. Along with the myelination of the axon, the diameter of the axon can infuence the speed of conduction. Much as water runs faster in a wide river than in + a narrow creek, Na -based depolarization spreads faster down a wide axon than down a narrow one. This concept is known as resistance and is generally true for electrical wires or plumbing, just as it is true for axons, although the specifc conditions are diferent at the scales of electrons or ions versus water in a river. The concentrations of ions in the extracellular fuid are the basis for how the membrane potential is established and changes in electrochemical signaling. After the repolarizing phase + + + of the action potential, K leakage channels and the Na /K pump ensure that the ions return to their + original locations. Astrocytes can become reactive in cases such as these, which impairs their ability to maintain the local + chemical environment. They lose their K bufering + ability and the function of the pump is afected, or even reversed. If a Na gradient breaks down, this has a more important efect than interrupting the action potential. Visit this site to see a virtual neurophysiology lab, and to observe electrophysiological processes in the nervous system, where scientists directly measure the electrical signals produced by neurons. Often, the action potentials occur so rapidly that watching a screen to see them occur is not helpful. A speaker is powered by the signals recorded from a neuron and it “pops” each time the neuron fres an action potential. These action potentials are fring so fast that it sounds like static on the radio. Electrophysiologists can recognize the patterns within that static to understand what is happening. Why is the leech model used for measuring the electrical activity of neurons instead of using humans? A stimulus starts the depolarization, but the action potential runs on its own once a threshold has been reached. These special types of potentials infuence a neuron and determine whether an action potential will occur or not. Graded Potentials Local changes in the membrane potential are called graded potentials and are usually associated with the dendrites of a neuron. The amount of change in the membrane potential is determined by the size of the stimulus that causes it.

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